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July 14, 1978

Delayed Hemolytic Transfusion Reactions

Author Affiliations

St Joseph Hospital Chicago

JAMA. 1978;240(2):110-111. doi:10.1001/jama.1978.03290020032013

To the Editor.—  Solanki and McCurdy did a service to the profession by focusing recently on the phenomenon of delayed hemolytic transfusion reactions (239:729, 1978). They report that all their eight patients were black, had multiple alloantibodies, and survived without major untoward results. They quote only one case from the literature (204:1007, 1968) of "renal failure with delayed transfusion reactions" and consider this "unusual."In 1963 del Greco and I1 reported an acute hemolytic transfusion reaction due to an anti-K antibody in a patient who was transfused ten years earlier and in whom cross matching was negative just prior to the transfusion in question. Acute renal failure developed in that patient, but he ultimately recovered after repeated hemodialysis. A 1:16 anti-K antibody titer became detectable 72 hours after the transfusion. Such reactions can be fatal2 (167:1736, 1958).In 1966 we again reported a delayed hemolytic transfusion reaction due