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July 14, 1978

Vascular Grafts

Author Affiliations

Columbia Physicians Center Evansville, Ind

JAMA. 1978;240(2):149-150. doi:10.1001/jama.1978.03290020071034

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In 1951, vascular grafts were first fashioned out of nylon parachutes. Since then, basic scientists, manufacturers, and physicians have joined together to develop better arterial replacement materials. In regard to these substances, however, conflicting claims of their antithrombogenicity and long-term patency continue to confuse us. To put the dilemma into useful perspective, this text assembles the 39 papers and discussions presented at a 1976 symposium.

The book initially addresses such items as durability (ultra lightweight Dacron may dilate and disrupt a few years after implantation), nonthrombogenicity (the measurable attributes of thromboresistant surfaces are just now being defined), and porosity (an optimal porosity for every fabric exists to admit just the proper amount of neoendothelialization). Of the other factors important at the blood-synthetic interface, platelets and details of polymer manufacture receive substantial attention. Drawn polymers, for example, may contain defects that admit lipids; these fats can act as "osmotic disruptive microtimebombs"