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July 21, 1978

Peliosis Hepatis Associated With Administration of Oxymetholone

Author Affiliations

From the Department of Pathology, Wilford Hall USAF Medical Center, Lackland Air Force Base, San Antonio, Tex.

JAMA. 1978;240(3):243-244. doi:10.1001/jama.1978.03290030061023

PELIOSIS hepatis is an unusual cystic lesion of the liver that was first recognized as a discrete entity by Schoenlank1 in 1916. To our knowledge, only three cases have been diagnosed antemortem; in one instance, the lesion regressed following discontinuation of oxymetholone therapy.2-4

We report the case of a patient with Hodgkin's disease, who was found to have peliosis hepatis after receiving oxymetholone.

Report of a Case  A 21-year-old man was examined in April 1970, with a three-week history of malaise, weight loss, night sweats, hectic fevers, anorexia, and pruritus.The patient was severely ill with cervical adenopathy and splenomegaly. Biopsy of a cervical lymph node showed nodular sclerosing Hodgkin's disease. Baseline liver function tests were normal, and an initial hematocrit level was 31%.Oxymetholone was first used in early November 1974. The patient received 30 mg per day, orally, and was followed up closely to detect any