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Article
July 21, 1978

Peliosis Hepatis Associated With Administration of Oxymetholone

Author Affiliations

USAF; USAF
From the Department of Pathology, Wilford Hall USAF Medical Center, Lackland Air Force Base, San Antonio, Tex.

JAMA. 1978;240(3):243-244. doi:10.1001/jama.1978.03290030061023
Abstract

PELIOSIS hepatis is an unusual cystic lesion of the liver that was first recognized as a discrete entity by Schoenlank1 in 1916. To our knowledge, only three cases have been diagnosed antemortem; in one instance, the lesion regressed following discontinuation of oxymetholone therapy.2-4

We report the case of a patient with Hodgkin's disease, who was found to have peliosis hepatis after receiving oxymetholone.

Report of a Case  A 21-year-old man was examined in April 1970, with a three-week history of malaise, weight loss, night sweats, hectic fevers, anorexia, and pruritus.The patient was severely ill with cervical adenopathy and splenomegaly. Biopsy of a cervical lymph node showed nodular sclerosing Hodgkin's disease. Baseline liver function tests were normal, and an initial hematocrit level was 31%.Oxymetholone was first used in early November 1974. The patient received 30 mg per day, orally, and was followed up closely to detect any

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