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August 18, 1978

Malignant Neoplasms Following Cardiac Transplantation

Author Affiliations

From the Divisions of Oncology (Dr Krikorian) and Cardiology (Dr Anderson), and Department of Cardiovascular Surgery (Drs Bieber and Stinson), Stanford University School of Medicine, Stanford, Calif; and Department of Surgery (Dr Penn), University of Colorado Medical School, and Denver Veterans Administration Hospital (Dr Penn), Denver.

JAMA. 1978;240(7):639-643. doi:10.1001/jama.1978.03290070041012

Between Jan 6, 1968, and April 11, 1977, 124 patients underwent cardiac transplantation at Stanford University Medical Center, with a mean and median period of follow-up of 18.3 and 9.7 months, respectively. Malignant neoplasms developed in seven patients—three lymphoproliferative neoplasms, two skin cancers, one acute leukemia, and one colon carcinoma. Visceral tumors were often fatal and caused 11% of deaths after three months following transplantation. The incidence and spectrum of malignant neoplasms in this population are similar to those observed in recipients of renal homografts.

(JAMA 240:639-643, 1978)