Between Jan 6, 1968, and April 11, 1977, 124 patients underwent cardiac transplantation at Stanford University Medical Center, with a mean and median period of follow-up of 18.3 and 9.7 months, respectively. Malignant neoplasms developed in seven patients—three lymphoproliferative neoplasms, two skin cancers, one acute leukemia, and one colon carcinoma. Visceral tumors were often fatal and caused 11% of deaths after three months following transplantation. The incidence and spectrum of malignant neoplasms in this population are similar to those observed in recipients of renal homografts.
(JAMA 240:639-643, 1978)
Krikorian JG, Anderson JL, Bieber CP, Penn I, Stinson EB. Malignant Neoplasms Following Cardiac Transplantation. JAMA. 1978;240(7):639–643. doi:10.1001/jama.1978.03290070041012
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