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September 8, 1978

Prolonged Anuria in Wegener's Granulomatosis: Recovery of Renal Function

Author Affiliations

From the Department of Internal Medicine, Kantonsspital Aarau, Switzerland.

JAMA. 1978;240(11):1174-1175. doi:10.1001/jama.1978.03290110072025

IN WEGENER'S granulomatosis with renal involvement, the outcome had been uniformly fatal until cytotoxic therapy was found to dramatically alter the course of the disease. We describe a patient with remarkable recovery of renal function while receiving cyclophosphamide therapy after prolonged anuria.

Report of a Case  A 24-year-old woman was well until April 1976, when a fistula developed in the scar of a uterotomy performed five years earlier. In May, she had severe otitis media on the left, with hearing loss and perforation of the tympanic membrane. An excision of the abdominal fistula was done in July; the histologic examination showed chronic granulomatous inflammation. In August, polyarthralgia and otitis media on the right and facial nerve palsy on the left developed. A mastoidectomy was performed because of mastoiditis; a histologic examination was not done.On Sept 10, she was admitted to another hospital because of prostration, fever, and ulcerations of