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September 15, 1978

Aerosol Beclomethasone Treatment of Chronic Severe Asthma: A One-Year Experience

Author Affiliations

From the Department of Medicine, Allergy-Immunology Section, University of Wisconsin Center for the Health Sciences, Madison.

JAMA. 1978;240(12):1260-1262. doi:10.1001/jama.1978.03290120054026

After one year's use of beclomethasone dipropionate aerosol, 43 of 61 asthmatic patients who were originally dependent on oral corticosteroids were able to reduce and 38 to completely eliminate use of oral corticosteroids. Most patients maintained or improved their pulmonary functions. Exacerbation of rhinitis during oral corticosteroid withdrawal and emergence of nasal polyps were problems for 25 patients. Exacerbation of asthma with upper respiratory infections was an important event: 21 patients required supplemental oral corticosteroids to control asthma. Oral candidiasis occurred in only three patients.

(JAMA 240:1260-1262, 1978)