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October 13, 1978

Renal Vein ThrombosisComplication of Primary Renal Disease and the Nephrotic Syndrome

JAMA. 1978;240(16):1747-1748. doi:10.1001/jama.1978.03290160065027

THE ASSOCIATION between renal vein thrombosis and the nephrotic syndrome is well documented in the literature. Although some investigators have suggested that renal vein thrombosis precedes the onset of the nephrotic syndrome and hence serves as the initiating event,1 more recent observations imply that the nephrotic syndrome usually precedes the development of renal vein thrombosis. We report such a progression of events in a patient who had the nephrotic syndrome and in whom idiopathic membranous glomerulonephritis was found on histologic examination of the kidney. Later, renal vein thrombosis complicated the course of the patient's illness.

Report of a Case  A 54-year-old man was hospitalized with peripheral edema, mild hypertension, and proteinuria of three months' duration. The blood pressure on admission was 150/80 mm Hg, and there was pitting edema (2+) to the level of the knees bilaterally. Results of the remaining aspects of the physical examination were unremarkable. Evaluation