To the Editor.—
In their article entitled "Extensive Metastases in Peutz-Jeghers Syndrome" (239:2268, 1978), Ryo and associates refer to an article by Reid (229:833, 1974) to state that there are 14 known cases of malignant neoplasms developing from the Peutz-Jeghers polyp and that the rate of malignant transformation in these polyps is 2% to 3%. Reid reviewed 14 cases of digestive malignant neoplasms in the Peutz-Jeghers syndrome, and, in fact, in only two of his reviewed cases1,2 is there acceptable proof that the malignant neoplasm originated from a typical hamartomatous polyp. The 2% to 3% incidence of malignancy in this syndrome as stated by Reid refers to all digestive cancers and not only to those developing in hamartomatous polyps as Ryo et al seem to imply. In fact, besides the two cases in Reid's review and the one reported by Ryo et al, there is only one other case
Major P. Malignant Neoplasm in Peutz-Jeghers Syndrome. JAMA. 1978;240(20):2155. doi:10.1001/jama.1978.03290200033012
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