Hypocupremia occurred in an adult with sickle cell anemia who received zinc as an antisickling agent for two years. The hypocupremia was associated with microcytosis and relative neutropenia. Administration of copper resulted in an increase in RBC size and leukocyte counts. We have since observed hypoceruloplasminemia of varying degrees in several other sickle cell anemia patients who were receiving oral zinc therapy. This complication was easily corrected by copper supplementation.
(JAMA 240:2166-2168, 1978)
Prasad AS, Brewer GJ, Schoomaker EB, Rabbani P. Hypocupremia Induced by Zinc Therapy in Adults. JAMA. 1978;240(20):2166–2168. doi:10.1001/jama.1978.03290200044019
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: