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November 10, 1978

Autoimmunity: Genetic, Immunologic, Virologic, and Clinical Aspects

Author Affiliations

University of Washington Seattle

JAMA. 1978;240(20):2198. doi:10.1001/jama.1978.03290200076034

This book, the product of 40 different contributors from eight countries, is divided into four major parts. The first is devoted to genetic aspects: the major histocompatibility complex and disease, the genetics of autoimmune disease in animals, and the genetic regulation in autoimmune thyroiditis. Part 2 discusses concepts of pathogenesis, self-recognition and tolerance, suppressor T-cell dysfunction, lymphoid malignant neoplasms, thymic hormones, and the biology of immune complexes. Part 3 studies the influence of viral infection on the immune response. The last part consists of nine clinically related chapters that deal with immunodeficiency, aging, and receptor autoimmunity, with three whole chapters given to systemic lupus erythematosus, rheumatoid arthritis, and neurologic disease. The book concludes on a positive theme with a chapter on the possible beneficial role of certain autoimmune phenomenons. Each chapter is an extensively referenced review that could stand on its own in a medical journal, and each can serve