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September 25, 1981

Clinical Immunology of the Heart

JAMA. 1981;246(13):1467. doi:10.1001/jama.1981.03320130065033

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Clinical Immunology of the Heart provides an important introduction to immunologic diagnosis, cellular immunity, and immunogenetics for practicing cardiologists and others interested in cardiovascular disease. The application of the techniques and knowledge in this book will undoubtedly produce much new, valuable information and better understanding of heart disease mechanisms in the future.

Chapter 1 emphasizes immunologic methods in cardiology applicable to cardiac diseases of presumed immunologic origin. Chapter 2 reveals how antibodies can be used for sensitive measurements of immunologic changes in vitro and even therapeutically. For example, purified digoxinspecific Fab fragments may be used to reverse advanced digoxin intoxication in man. Chapter 3 discusses immunologic concepts in rheumatic fever, particularly those relating group A streptococcus to the clinical and pathological events implicated in rheumatic fever and rheumatic heart disease. Evidence of a persistent genetic marker for rheumatic fever throughout life, coupled with recurrences of rheumatic fever in older people,