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December 1, 1978

Thrombocytopenia Associated With Antiheparin Antibody

Author Affiliations

From the Department of Medicine, the University of Kansas Medical Center, College of Health Sciences and Hospital, Kansas City.

JAMA. 1978;240(23):2560-2562. doi:10.1001/jama.1978.03290230052025

Thrombocytopenia developed in a 69-year-old woman receiving heparin sodium therapy for deep-vein thrombosis. Bone marrow and platelet survival studies suggested peripheral destruction of platelets. The serum factor associated with thrombocytopenia was shown to be an IgM immunoglobulin. Heparin-induced thrombocytopenia may be a common side effect of heparin therapy and should be evaluated to avoid serious consequences.

(JAMA 240:2560-2562, 1978)