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December 8, 1978

Megavitamins for Minimal Brain Dysfunction: A Placebo-Controlled Study

Author Affiliations

From the Departments of Psychiatry (Drs Arnold and Smeltzer) and Pediatrics (Dr Arnold), Ohio State University, Columbus; the Department of Psychiatry (Dr Christopher), Richland Neuropsychiatric Hospital, Mansfield, Ohio; and the Holzer Medical Center Clinic (Dr Huestis), Gallipolis, Ohio.

JAMA. 1978;240(24):2642-2643. doi:10.1001/jama.1978.03290240042021

Preliminary to a stimulant comparison study, 31 children with minimal brain dysfunction randomly received either placebo or a megavitamin combination. During a two-week trial, only two children responded so well that stimulants were not considered necessary; both were in the placebo group. Change scores from pretest to posttest on four blind ratings by teachers and parents did not show a significant difference between the placebo and vitamin groups.

(JAMA 240:2642-2643, 1978)