Preliminary to a stimulant comparison study, 31 children with minimal brain dysfunction randomly received either placebo or a megavitamin combination. During a two-week trial, only two children responded so well that stimulants were not considered necessary; both were in the placebo group. Change scores from pretest to posttest on four blind ratings by teachers and parents did not show a significant difference between the placebo and vitamin groups.
(JAMA 240:2642-2643, 1978)
Arnold LE, Christopher J, Huestis RD, Smeltzer DJ. Megavitamins for Minimal Brain DysfunctionA Placebo-Controlled Study. JAMA. 1978;240(24):2642–2643. doi:10.1001/jama.1978.03290240042021
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