Resin hemoperfusion was used in a long-term dialysis patient who inadvertently ingested a quadruple dose of digoxin for five days. Severe gastrointestinal symptoms improved, and impressive plasma digoxin clearances were observed. Cellulose-coated activated charcoal was used in another patient who had ingested a massive dose of digoxin. Gastrointestinal and CNS symptoms improved, and second-degree heart block with life-threatening bradycardia cleared during hemoperfusion. Digoxin toxicity may be added to the list of conditions that can be treated by this method.
(JAMA 240:2736-2737, 1978)
Smiley JW, March NM, Guercio ETD. Hemoperfusion in the Management of Digoxin Toxicity. JAMA. 1978;240(25):2736–2737. doi:10.1001/jama.1978.03290250040024
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