In 1971 participants in the Ann Arbor Conference on Hodgkin's disease thought that pruritus had no independent prognostic importance. We reviewed our series of patients with Hodgkin's disease and found six patients in whom severe itching was a major clinical problem. When compared with similarly treated patients without pruritus, these patients appeared to have more-aggressive disease. Severe itching, alone or with B symptoms, needs further study, since it may presage a poor prognosis.
(JAMA 240:2738-2740, 1978)
Feiner AS, Mahmood T, Wallner SF. Prognostic Importance of Pruritus in Hodgkin's Disease. JAMA. 1978;240(25):2738–2740. doi:10.1001/jama.1978.03290250042025
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