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February 23, 1979

Rupture of the Spleen in Amyloidosis

Author Affiliations

Baylor College of Medicine Texas Medical Center Houston

JAMA. 1979;241(8):790-791. doi:10.1001/jama.1979.03290340014009

To the Editor.—  Amyloidosis includes a group of disorders with a variety of clinical features that generally are a result of the deposition of a proteinaceous, finely fibrillar, eosinophilic, hyaline extracellular substance.1 The diagnosis of amyloidosis is established by histological examination and special stains of tissue obtained by biopsy or, more commonly, at autopsy. The clinical manifestations of the disease are usually subtle and nonspecific. The following case of amyloidosis is noteworthy because the patient's initial condition was that of an acute abdomen secondary to rupture of the spleen.

Report of a Case.—  A 49-year-old man was brought to the Ben Taub General Hospital emergency room with a complaint of left upper quadrant abdominal pain that had become progressively worse during several days. He gave no history of trauma or abdominal injury in the previous week. He denied past specific chronic or acute illnesses. However, he did state that