To the Editor.—
The article entitled "Ventricular Tachycardia Associated With Non-Freon Aerosol Propellants" by Wason et al1 is misleading. The conclusion that hydrocarbon aerosol propellants are toxic and responsible for ventricular tachycardia in a 2-year-old girl is unfounded in view of the published toxicity levels of hydrocarbon aerosol propellants.Toxic levels of the butanes were not demonstrated or quantified. Exposure and dosage amounts were not determined. Other factors that could cause ventricular tachycardia were not considered. Animal and human studies on the toxicity of hydrocarbon aerosol propellants and the child's probability of exposure preclude the conclusion that hydrocarbon aerosol propellants are toxic.Wason et al reported the presence of the butanes (isobutane and n-butane) and acetone in the child's blood serum. Toxic levels were not demonstrated quantitatively.Hydrocarbon inhalation studies in mice and rats have established a median lethal concentration (LC50) of 680 mg/L (two-hour exposure) and
McCain HB, Ebrahim AR. Ventricular Tachycardia Associated With Non-Freon Aerosol Propellants. JAMA. 1987;257(1):26. doi:10.1001/jama.1987.03390010030011
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