Case-mortality and survival rates of more than 2,000 prevalent cases of multiple sclerosis (MS) residing in either Los Angeles County, California, or King and Pierce Counties, Washington, and followed up for 105 months, are reported. Case-mortality at the end of the 105 months was 16.9% of the total group. All age and sex groups had a lower survival rate than the US general population; this difference was especially pronounced in the high-disability groups. There was a trend toward higher case-mortality in high-disability Los Angeles County patients when compared with high-disability patients from King and Pierce Counties.
Roberta M. Malmgren, Jan P. Dudley, Barbara R. Visscher, Nora L. Valdiviezo, Virginia A. Clark, Roger Detels. Mortality in Persons With Multiple Sclerosis in the Seattle and Los Angeles Areas. JAMA. 1981;246(18):2042–2045. doi:10.1001/jama.1981.03320180034025