To the Editor.—
An increased incidence of thyroid autoantibodies is known to occur in patients with Turner's syndrome.1,2 The disorders closely related to thyroid autoantibodies are Hashimoto's disease and Graves' disease. A striking association of Hashimoto's disease with Turner's syndrome, especially due to structural variations of an X chromosome, has been repeatedly shown.1-4 Yet, Graves' disease has rarely been documented in patients with this chromosomal abnormality.4
Report of a Case.—
When this woman was born, a karyotype of 45,XO (Turner's syndrome) was determined during the investigation of bilateral pedal edema. The physical findings included hypertelorism, slight cubitus valgus, and a widely spaced nipple. A webbed neck, a low hairline, and multiple, pigmented nevi were absent. At age 11 years, because of the absence of secondary sex characteristics, she was given a conjugated estrogen preparation for two years, followed by the addition of medroxyprogesterone for the onset of
Hirano T. Association of Graves' Disease With Turner's Syndrome. JAMA. 1981;246(21):2429. doi:10.1001/jama.1981.03320210011004
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