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June 22, 1979

Transient Global Amnesia-Reply

Author Affiliations

Rush Medical College Presbyterian-St Luke's Medical Center Chicago

JAMA. 1979;241(25):2703. doi:10.1001/jama.1979.03290510017016

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Like Dr Kennedy and his colleagues, we considered the possibility that TGA may be an epileptogenic condition. Electroencephalograms were obtained in 29 of the patients whose cases were reported in our series. In no case was the recording obtained during an amnestic episode, although most were obtained within a few days of the event. Review of these records showed 28 EEGs to be normal. One record demonstrated a right frontotemporal slow wave focus without spikes. A brain scan and carotid arteriogram failed to disclose any abnormalities, and no associated neurological deficits were present. During the subsequent two years, this patient was well, with no recurrence of amnesia. None of the patients in our series subsequently reported the occurrence of a convulsion during the follow-up period. No patients received anticonvulsant therapy.

Based on our experience, we do not believe that most cases of TGA are epileptic in origin. While