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June 22, 1979

Use of Mefenamic Acid in the Treatment of Primary Dysmenorrhea

Author Affiliations

From the Department of Clinical Family Medicine, School of Medicine, State University of New York at Stony Brook.

JAMA. 1979;241(25):2713-2716. doi:10.1001/jama.1979.03290510021018

Mefenamic acid (Ponstel), 250 mg four times a day, and placebo were compared in a double-blind, crossover study conducted in 46 women with primary spasmodic dysmenorrhea. When compared with placebo, treatment with mefenamic acid resulted in significant decreases in the frequency and severity of the symptoms, and significantly reduced the need for additional analgesic medication. Mefenamic acid was well tolerated. No changes in clinical laboratory values were associated with its use.

(JAMA 241:2713-2716, 1979)