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December 11, 1981

Bone Metastasis

Author Affiliations

Michael Reese Hospital and Medical Center Chicago

JAMA. 1981;246(23):2748. doi:10.1001/jama.1981.03320230064033

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This book is the fourth volume of a series on metastasis by Drs Weiss and Gilbert. Metastasis is inherent to the biology of a malignant tumor; yet, oncologists (surgical, medical, or radiation) have little knowledge of how this biologic process occurs. In this volume, Weiss and Gilbert elucidate the complex phenomenon of metastases to bone.

This monograph is divided into six parts, dealing with the pathophysiology of bone metastases, diagnosis, rehabilitation, and drug, surgical, and radiation therapy. The first part of the monograph, entitled "A Background to Metastasis in Bone," gives an excellent discussion of how tumor cells are shed, the importance of the perivertebral vein system, and the mechanisms of bone destruction by tumor cells. The chapters by Drs Gullino, Mundy, and Batson are outstanding and should be considered "required reading" by oncologists. The parts on drug and radiation therapy provide the reader with an excellent overview of current