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December 18, 1981

Aspirin and Perioperative Blood Loss-Reply

Author Affiliations

Massachusetts General Hospital Boston

JAMA. 1981;246(24):2808. doi:10.1001/jama.1981.03320240018014

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In Reply.—  Dr Michelson writes that "I cannot agree with the statement... that an average additional blood loss of 400 mL 'is not of great clinical importance.' "Our overall figures of blood loss include eight different groups of patients. That is to say, we compared patients with primary operations who then had normotensive or hypotensive anesthesia and broke those groups down into patients who received 1.2 or 3.6 g of aspirin a day. There was a second major group composed of patients undergoing revision total-hip arthroplasty. They received either normotensive or hypotensive anesthesia, and each of those groups was subdivided into patients receiving 1.2 vs 3.6 g of aspirin a day. The results in all of these subsets were then compared with those of control subjects who had the corresponding characteristics, ie, primary or secondary total-hip replacement and normotensive or hypotensive anesthesia.If Dr Michelson refers to Table 3, he