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January 15, 1982

Nitrous Oxide-Oxygen Sedation

JAMA. 1982;247(3):302. doi:10.1001/jama.1982.03320280024007

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To the Editor.—  I compliment Griffin et al on their recent report on the successful use of nitrous oxide-oxygen sedation in their pediatric practice. However, I strongly disagree with their statement that they consider the use of diazepam~with nitrous oxide-oxygen sedation to be contraindicated (unless, perhaps, they were referring specifically to their pediatric population).We have used (as have others) nitrous oxide-oxygen sedation with carefully titrated intravenously (IV) administered diazepam for several years in plastic surgical procedures performed on adults under local anesthesia. We have found this combination of sedative agents to be safe and effective. Our anesthesiologist colleagues share this opinion.I regret that such a statement with the word "contraindicated" becomes part of the literature, and I submit this letter to refute it.