To the Editor.—
In commenting on the negative correlation between serum cholesterol and colon cancer reported by the Framingham group (1981; 245:247), Albert B. Lowenfels, MD, asked if there is any relation between gallstones, serum cholesterol, and colon cancer (1981;246:213). In our prospective study of 8,006 examined men, we also observed that subjects with a low serum cholesterol level had an increased risk for colon cancer.1 However, the 189 subjects in our study who subsequently had a cholecystectomy after examination did not have low serum cholesterol levels before their operative procedure. Their age-adjusted mean level was 218.4 mg/dL, compared with 218.3 mg/dL for the rest of the study population.There were too few incident cases (only three) of colon cancer occurring among the 121 subjects who had had cholecystectomy before examination for any meaningful analysis at this time.Dr Lowenfels mentioned the possibility that some persons with a low serum
Nomura AMY, Stemmermann GN, Heilbrun LK. Serum Cholesterol and Colon Cancer. JAMA. 1982;247(3):304. doi:10.1001/jama.1982.03320280026013
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