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January 22, 1982

Stomatitis Associated With Zomepirac

JAMA. 1982;247(4):461-462. doi:10.1001/jama.1982.03320290011010

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To the Editor.—  Zomepirac sodium is a potent nonnarcotic analgesic that has recently been introduced in the United States for the treatment of mild to moderately severe pain. We recently noted a case of stomatitis that was apparently related to zomepirac administration.

Report of a Case.—  The patient was a 63-year-old woman with a 15-month history of adenocarcinoma of the lung and gastrointestinal intolerance to multiple analgesics. She was admitted for control of pain. Because of inadequate pain relief with orally administered morphine sulfate solution, treatment with zomepirac sodium was initiated at a dose of 100 mg every six hours on demand. The following day she required less morphine and her mental status and appetite improved. On Jan 9, 1981, the zomepirac was changed from a demand schedule to every six hours around the clock. Intense erythematous stomatitis and tongue pain were noted on Jan 10, the zomepirac was withdrawn,