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Dr Denniston presents an interesting suggestion to explain an association between spermicide use and unfavorable outcome of pregnancy. He is, however, incorrect in stating that the associated malformations found in our study were "random." The increased rates of malformation in the spermicide group were restricted to a few uncommon disorders. There was no association with congenital heart disease, cleft palate, and the other malformations studied.
Jick H. Spermicides and Birth Defects-Reply. JAMA. 1982;247(4):462–463. doi:10.1001/jama.1982.03320290012015
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