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February 5, 1982


JAMA. 1982;247(5):692-693. doi:10.1001/jama.1982.03320300088042

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This book is a compilation of papers by different authors on vasodilatation both in animals and man, including several papers authored or coauthored by one of the editors (Vanhoutte). Like all such books, the quality is uneven, some papers being excellent and others less so.

Many papers raise more questions than they answer. For example, the exact biochemical mechanism of action of such drugs as hydralazine and minoxidil remains obscure. The coverage is also uneven, since there are many papers on the cerebral, skin, and muscle circulations but few or none on the renal, hepatic, and splanchnic circulations. The coronary and pulmonary circulations are also somewhat neglected. In addition, the angiotensin-aldosterone system is given short shrift except to indicate its vasodilating properties under certain circumstances. Many vasodilators are mentioned only casually or not at all, such as guanethidine sulfate, reserpine, saralasen acetate, captopril, and hydrochlorathiazide, and the mechanism for vasodilatation