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November 30, 1979

Effects of Estrogens on Sleep and Psychological State of Hypogonadal Women

Author Affiliations

From the Menopausal Unit, Boston Hospital for Women; and the Departments of Obstetrics and Gynecology (Drs Schiff, Tulchinsky, and Ryan) and Psychiatry (Dr Regestein), Harvard Medical School, Boston.

JAMA. 1979;242(22):2405-2407. doi:10.1001/jama.1979.03300220017014

A double-blind crossover study involving 16 hypogonadal women compared the effects of placebo and cunjugated estrogens, 0.625 mg daily, on gonadotropin levels, symptoms, sleep patterns, and psychological state. After one month, serum concentrations of follicle-stimulating hormone fell 31%, and levels of luteinizing hormone, 19%; the number of vasomotor flushes also decreased. The administration of estrogens was also associated with a shorter mean sleep latency, a longer period of rapid eye movement sleep, and a positive correlation between psychological intactness (as clinically ranked) and latency to sleep onset. Psychological testing, including the Clyde Mood Scale, and the Gottschalk-Gleser Test indicated that estrogens caused this group to be less outwardly aggressive but more inwardly hostile.

(JAMA 242:2405-2407, 1979)