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February 12, 1982

Detection of Gastrointestinal Bleeding Sites: Use of In Vitro Technetium Tc 99m—Labeled RBCs

Author Affiliations

From the Nuclear Medicine Service, Department of Radiology, Letterman Army Medical Center, Presidio of San Francisco (Drs Bunker, Brown, McAuley, Jackson, and Lull), and the Nuclear Medicine Section, Department of Radiology, University of California Medical Center, San Francisco (Dr Hattner and Mr Huberty). Dr Bunker is currently with the Department of Radiology, Brooke Army Medical Center, San Antonio, Tex.

JAMA. 1982;247(6):789-792. doi:10.1001/jama.1982.03320310037025

Sixteen patients clinically suspected of having gastrointestinal hemorrhage were studied by abdominal scintigraphy with RBCs labeled in vitro with technetium Tc 99m. Ten of 11 actively bleeding patients had positive scintigrams, with bleeding localized to the duodenum in one, ascending colon in five, sigmoid colon in six, and rectosigmoid colon in one. Scintigraphic findings were corroborated by clinical, endoscopic, arteriographic, and surgical findings. Retention of this blood-pool radiotracer in the vascular compartment allows noninvasive diagnosis of acute, as well as slow or intermittent, bleeding for up to 24 hours after intravenous administration.

(JAMA 1982;247:789-792)