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December 14, 1979

Cooperative Clofibrate Trial

JAMA. 1979;242(24):2663-2664. doi:10.1001/jama.1979.03300240009007

To the Editor.—  I am concerned about the closing statement in the editorial on the Cooperative Clofibrate Trial (241:2638,1979), which I think did not represent the statements and views of the principal investigators.The principal investigators did not recommend clofibrate for use in community-wide programs.1,2 The report in the British Heart Journal stated, "The trial confirmed the basic hypothesis that reduction of high serum cholesterol levels even in middle age can reduce the incidence of ischaemic heart disease." In their general comments on page 1101, the investigators listed a number of factors that might have led to more striking results. One of these was that the duration of the lowering, of lipid levels in the study might not have been long enough to influence long-standing coronary artery disease.The belief in the lipid hypothesis has stimulated many public health programs aimed at reducing serum cholesterol levels in hopes of