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February 12, 1982

Metabolites and Analogues of Vitamin D: Which for What?

Author Affiliations

From the Department of Biochemistry, University of Arizona Health Sciences Center, Tucson (Dr Haussler), and the Section of Nephrology, St Joseph's Hospital and the University of Western Ontario, London (Dr Cordy).

JAMA. 1982;247(6):841-844. doi:10.1001/jama.1982.03320310085047

The discovery and chemical synthesis of several biologically active derivatives of vitamin D have increased the number of compounds available for the treatment of disorders of bone and mineral metabolism. Calcitriol is the most active natural metabolite of vitamin D, but analogues like dihydrotachysterol and calcifediol also are safe and effective therapeutic agents. These vitamin D congeners have been useful in the treatment of renal osteodystrophy, hypoparathyroidism, and other disorders refractory to vitamin D therapy. Certain analogues may offer distinct advantages over vitamin D, depending on the nature of the defect. All vitamin D derivatives should be used cautiously, with frequent monitoring of serum calcium levels to prevent toxic reactions.

(JAMA 1982;247:841-844)