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February 12, 1982

The Slow Inward Current and Cardiac Arrhythmias

JAMA. 1982;247(6):886. doi:10.1001/jama.1982.03320310112054

This is a timely and unique publication. Despite its 1980 copyright and the two years that have passed since its preparation, the book retains its accuracy and immediacy. It represents a new compilation of information regarding the kinetically slow inward current. Coverage of the subject is remarkably complete. This text will be required reading as an important and singular reference source for any basic or clinical scientist who intends to study the cardiac calcium channel.

Since Reuter and other investigators convincingly demonstrated 15 years ago the existence of a small, prolonged inward current occurring during the plateau of the cardiac action potential, activated at low transmembrane potentials and dependent on calcium rather than sodium ion, a huge quantity of research data characterizing this current has been amassed. These data are summarized and interpreted succinctly in this book by 37 respected investigators who are, in fact, largely responsible for the existence