[Skip to Content]
[Skip to Content Landing]
February 26, 1982

Aortic Thrombosis in Antithrombin III Deficiency

JAMA. 1982;247(8):1127. doi:10.1001/jama.1982.03320330023016

To the Editor.—  Although we are told in the article by Michael E. Shapiro, MD, and Edwin W. Salzman, MD (1981;245:1759), that abnormal antithrombin III (AT III) levels were documented in both cases weeks to months after any short-term event or surgery, in case 1 the reduced AT III level was found at a time when resting pain had been present for three weeks, and arteriography demonstrated complete occlusion of the right common iliac and left common femoral arteries. In case 2 the time of sampling is unstated but seemed to coincide with the presence of gangrenous changes and new femoral, superficial femoral, and popliteal thromboses.In conditions where activation of the coagulation system takes place, such as acute venous thrombosis and disseminated intravascular coagulation, marked reductions in plasma AT III may be found.1 Thus, it seems possible that the observed low plasma AT III levels may have been