[Skip to Content]
[Skip to Content Landing]
March 14, 1980

Failure to Thrive and Metabolic Alkalosis: Adverse Effects of a Chloride-Deficient Formula in Two Infants

JAMA. 1980;243(10):1068-1070. doi:10.1001/jama.1980.03300360040024

This report concerns two infants with failure to thrive and hypochloremic metabolic alkalosis. Both infants were fed exclusively with a soybean-based formula, which, as a result of a manufacturing error, was severely deficient in chloride. When an alternative formula containing an adequate amount of chloride was prescribed, the electrolyte abnormality was corrected, and the infants resumed their normal weight gain.

(JAMA 243:1068-1070, 1980)