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March 14, 1980

Surreptitious Habitual Vomiting Simulating Bartter's Syndrome

JAMA. 1980;243(10):1070-1072. doi:10.1001/jama.1980.03300360042025

A patient with hypokalemic alkalosis, normotensive hyperreninism, hyperaldosteronism, increased levels of urinary and plasma prostaglandin E, and vascular hyporesponsivity to angiotensin II was thought to have Bartter's syndrome. Results of a kidney biopsy showed hyperplasia of the juxtaglomerular apparatus but no renomedullary cell hyperplasia. A 24-hour urine collection showed a low chloride level and no increase in the fractional chloride clearance, thus excluding Bartter's syndrome. Subsequent disclosure of surreptitious, habitual vomiting explained the hypokalemia.

(JAMA 243:1070-1072, 1980)