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March 21, 1980

Tricyclic Antidepressants for Peripheral Neuropathy-Reply

Author Affiliations

Veterans Administration Hospital Durham, NC

JAMA. 1980;243(11):1133. doi:10.1001/jama.1980.03300370013011

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In Reply.—  We thank Drs Massey and Riley for their observations, particularly for their suggestion that tricyclic antidepressant drugs may alter pain in part by affecting peripheral nerve transmission. A controlled study of the effects of tricyclic antidepressants on pain, such as the one they are proposing, would be helpful, indeed.