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Article
March 12, 1982

Medical News

JAMA. 1982;247(10):1381-1391. doi:10.1001/jama.1982.03320350003001

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Abstract

Coming: a 'Dear Doctor' letter that you may want to ponder  In the next few days, approximately 200,000 male physicians will receive a letter from Boston asking them to participate daily for "the next few years" in a cardiovascular and cancer research project.Those who qualify on the basis of their medical history and who agree to take part will be asked to swallow one tablet or capsule each day without knowing what either contains.A fourth of the approximately 20,000 expected participants, all of whom will be between the ages of 40 and 75 years, will take a standard 325-mg aspirin tablet (Bufferin) every other day and a 30-mg beta carotene capsule (Solatene) on the alternate days. The other three fourths will either take aspirin alternating with a placebo capsule, beta carotene alternating with a placebo tablet, or two placebos.The letter, signed by principal investigator Charles H.

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