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April 4, 1980

Cytomegalovirus-Associated Gastritis in a Compromised Host

JAMA. 1980;243(13):1364. doi:10.1001/jama.1980.03300390048023

CYTOMEGALOVIRUS (CMV) is a DNA virus of the herpes group. This virus may be acquired congenitally or by blood transfusion, most likely from infusion of leukocytes containing the virus,1 venereal transmission,2 or by direct transmission.1 Among healthy persons, infection is usually unapparent but may simulate infectious mononucleosis.3 Patients with immunologic abnormalities, either by virtue of their primary disease4 or their treatment,5 are highly susceptible to overt CMV infection. Hepatitis, pneumonitis, or other severe systemic involvement may be present. We report a case of rheumatoid arthritis in which the patient was receiving steroid and immunosuppressive therapy. Gastritis developed, and CMV was found to be the probable cause.

Report of a Case  A 56-year-old woman complained of epigastric pain unrelieved by food or antacids for two months. She was known to have had rheumatoid arthritis since the age of 39 years and had been treated with salicylates,