The case of a 23-year-old patient with sickle cell anemia and coexisting iron deficiency is described. The iron deficiency was not a result of phlebotomies, hematuria, or a gastrointestinal lesion, but was most likely the result of intravascular hemolysis and the rapid turnover of irreversibly sickled cells. This syndrome is commonly confused with sickle β'-thalassemia.
Natta C, Weiner MA, Chang H, Wolff JA, Fawaz R. Sickle Cell Anemia and Iron Deficiency: Resemblance to Sickle Thalassemia. JAMA. 1982;247(10):1442–1443. doi:10.1001/jama.1982.03320350046027
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