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June 6, 1980


JAMA. 1980;243(21):2202-2203. doi:10.1001/jama.1980.03300470062036

This year it seems appropriate to review three advances made in the basic aspects of ophthalmology that will be of great significance in our clinical work.

Transplantation of Cultured Corneal Endothelium  The corneal endothelium plays a primary role in determining the result of a keratoplasty. The transparency of the cornea depends on the activity of corneal endothelial cells. In the primate eye these endothelial cells have only a limited capability to repair defects; extensive endothelial wounds will result in edema and opacification of the corneal stroma.Corneal endothelial cells of various animals can now be cultured in a monolayer and kept alive through numerous passages.1 The cells remain active. They can be transplanted as a layer onto the denuded back surface of the cornea of an animal of a different species. The cells remain viable, and the cornea remains clear. Even cultured vascular endothelium can be used for such