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June 13, 1980

Extremely Shortened Activated Partial Thromboplastin Times

JAMA. 1980;243(22):2286. doi:10.1001/jama.1980.03300480012006

To the Editor.—  The presence of a hypercoagulable state in patients with a shortened activated partial thromboplastin time (APTT) as manifested by the clinical association with an increased incidence of thromboembolic disease has previously been reported by Hume,1 Gallus et al,2 Pilgeram,3 McKenna et al,4 and McKenna et al.5 A recent review of patients' clinical records at Southern Nevada Memorial Hospital showed that rather than a history of thrombosis, patients with extremely short (less than 20 s) APTTs actually had a history of spontaneous bleeding.All APTT results that were of a coagulation panel were reviewed during a seven-month period from Jan 1 to July 31, 1979. All APTTs of less than 20 s were selected for evaluation of the clinical chart provided that the patient had a simultaneous normal prothrombin time (less than 13 s), to determine the cause for the hospitalization and the