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January 15, 1988

You Don't Have to Be a Neuroscientist to Forget Everything With Triazolam—But It Helps

JAMA. 1988;259(3):351. doi:10.1001/jama.1988.03720030018011

To the Editor.  —The report by Morris and Estes1 warns against taking triazolam or other benzodiazepines to prevent jet lag, particularly if ethyl alcohol is consumed. The occurrence of transient global amnesia after taking triazolam actually "may be common"2 and not necessarily related to alcohol consumption or travel across time zones. Alternatively, it may be that stress and disrupted sleep trigger the abnormal response to benzodiazepine ingestion.

Report of a Case.  —A 29-year-old Italian neurologist took 0.5mg of triazolam to ensure a good night's sleep. He had not slept well during the previous week, feeling pressured by an upcoming move to the United States. After a light dinner, not including alcohol, he went to bed at 11 PM but did not sleep well. He awoke at 5 AM, had breakfast, caught a bus to the railroad station, and then took a train to another city, arriving three hours