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April 2, 1982

Complement defect linked to early strokes

JAMA. 1982;247(13):1803. doi:10.1001/jama.1982.03320380009005

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A deficiency of the second component of complement, called C2, may somehow be related to the occurrence of strokes in young people.

Speaking at the Joint International Conference on Stroke and Cerebral Circulation in New Orleans, neurologist Denis Simard, MD, described 11 patients with such deficiency. They were among 30 stroke victims under the age of 42 years admitted to the Hôpital l'Enfant-Jesus in Quebec city during the last two years. The mean age of the complement-deficient stroke victims was 27 years. (The mean age for stroke victims in the population at large is between 60 and 70 years.)

The 11 patients were identified during an extensive workup. In contrast, ten randomly selected older stroke patients (aged between 48 and 70 years) had normal C2 levels, said Simard. He added that the C2-deficient patients experienced fluctuations in their C2 levels during follow-up, but that the values never went back to