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April 2, 1982

Single-Dose Therapy for Cystitis

JAMA. 1982;247(13):1865-1866. doi:10.1001/jama.1982.03320380057032

Cystitis afflicts about 20% of women at least once in their lifetime.1 Although this infection is generally treated with antibiotics, in some cases it may resolve spontaneously.2 Therefore, courses of antimicrobial treatment shorter than the conventional seven to ten days, down to a single dose, have been investigated as a means of reducing the cost and side effects of treatment of this common infection. In this issue of The Journal (p 1839), Buckwold and co-workers extend a series of studies that report high rates of cure of urinary tract infection in women treated with single doses of antimicrobial agents that are excreted and concentrated in urine.

Despite the ease of clearing of bacteria from the urine initially with antimicrobial therapy to which the infecting pathogen is susceptible, some women are prone to relapse after single-dose treatment, or even after conventional therapy.3 The current study and some of the