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Article
February 12, 1988

Biomaterial-Centered Sepsis and the Total Artificial HeartMicrobial Adhesion vs Tissue Integration

Author Affiliations

From the Section of Orthopedic Surgery (Dr Gristina) and Department of Pathology (Dr Lewis), Wake Forest University Medical Center, Winston-Salem, NC; the Department of Biology Bellarmine College (Dr Dobbins), the Graduate Programs and Research, University of Louisville (Ms Giammara), and Humana Heart Institute International (Dr DeVries), Louisville.

From the Section of Orthopedic Surgery (Dr Gristina) and Department of Pathology (Dr Lewis), Wake Forest University Medical Center, Winston-Salem, NC; the Department of Biology Bellarmine College (Dr Dobbins), the Graduate Programs and Research, University of Louisville (Ms Giammara), and Humana Heart Institute International (Dr DeVries), Louisville.

JAMA. 1988;259(6):870-874. doi:10.1001/jama.1988.03720060038027
Abstract

The principal barrier to the extended use of the total artificial heart is infection that is centered on the biomaterial constituting the prosthetic device and exacerbated by the surrounding damaged tissue. Ultrastructural studies of total artificial hearts removed from two patients indicate a failure of true tissue integration and diffuse, adhesive bacterial colonization of biomaterial surfaces. Biomaterials are, in part, susceptible to infection because, at the present state of the art, they are usually not well integrated with host tissue or, if hemodynamic, not optimally biocompatible or antiadhesive.

(JAMA 1988;259:870-874)

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