Abstinence syndromes secondary to sedative-hypnotic drugs can occur in a wide range of clinical situations. The first such cases due to a combination analgesic product containing a barbiturate are reported. Cryptic abuse of combination prescription drugs can cause difficult diagnostic problems, such as the abstinence syndromes reported here. Each prescriber should know the individual agents contained in a combination preparation and their potential side effects.
(JAMA 244:369-370, 1980)
Preskorn SH, Schwin RL, McKnelly WV. Analgesic Abuse and the Barbiturate Abstinence Syndrome. JAMA. 1980;244(4):369–370. doi:10.1001/jama.1980.03310040051030
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