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April 16, 1982

Alternative Strategies to Randomized Clinical Trials-Reply

JAMA. 1982;247(15):2100. doi:10.1001/jama.1982.03320400020024

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In Reply.—  We thank Dr Van Peenen for pointing out that industrial hazards can be studied with the case-control method. The "novelty" of our approach was not the selection of patients from a closed cohort, but the analysis of data according to the same principles of eligibility and prognostic susceptibility that would have been used in a well-designed randomized trial of therapy. Neglect of these principles can lead to bias in studying the effects of either industrial or therapeutic agents.