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April 23, 1982

Isotope-tagged platelets used to locate thrombi

JAMA. 1982;247(16):2197-2201. doi:10.1001/jama.1982.03320410005002

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Visualization of platelet aggregates in aneurysms and atherosclerotic arteries is now possible using autologous platelets labeled with the radioactive isotope indium 111. These thrombi can throw off emboli that cause severe vascular damage in the lungs, brain, or limbs and that are "one of the primary causes of acute morbidity and death in the Western world," according to Michael D. Ezekowitz, MD, cardiologist at the University of Oklahoma Health Sciences Center in Oklahoma City.

At the recent Joint Conference on Stroke and Cerebral Circulation in New Orleans, three research groups, including that of Ezekowitz, discussed their findings with the radioisotope method. They agreed that it is accurate in some circumstances but needs further refinement before it becomes clinically useful on a routine basis. The same applies to another, similar use of the111In labeling technique—that of labeling autologous WBCs that are then reinfused into the patient and serve to