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September 19, 1980

Hyperaldosteronism, Hyperparathyroidism, Medullary Sponge Kidneys, and Hypertension

JAMA. 1980;244(12):1351-1353. doi:10.1001/jama.1980.03310120039020

Hyperparathyroidism and hyperaldosteronism coexisted in association with medullary sponge kidneys in a 27-year-old woman with severe hypertension. A modest fall in systolic and diastolic pressure followed removal of a parathyroid adenoma. Blood pressure was controlled with spironolactone therapy and restored to normal after removal of an aldosterone-secreting adrenal tumor. Elevated levels of aldosterone may have been responsible for the severe hypertension, while hypercalcemia may have had a synergistic effect on the arteriolar response to circulating vasoactive peptides.

(JAMA 244:1351-1353, 1980)